Hypertension - Introduction
High blood pressure, termed "hypertension," is a condition that afflicts almost 1 billion people worldwide and is a leading cause of morbidity and mortality. More than 20% of Americans are hypertensive, and one-third of these Americans are not even aware they are hypertensive. Therefore, this disease is sometimes called the "silent killer." This disease is usually asymptomatic until the damaging effects of hypertension (such as stroke, myocardial infarction, renal dysfunction, visual problems, etc.) are observed. Hypertension is a major risk factor for coronary artery disease, myocardial infarction ("heart attacks") and stroke.
Definition of Hypertension
Arterial blood pressure is "normal" when the systolic pressure is 90-119 mmHg and the diastolic pressure is 60-79 mmHg. When the arterial pressure is ≥120/80 mmHg, a person is said to be prehypertensive or hypertensive (see table below). Mean arterial pressure is also elevated in hypertension, but it is not usually measured in people. In past years, the diastolic value was emphasized in assessing hypertension. However, elevations in systolic pressure ("systolic hypertension") are also associated with increased incidence of coronary and cerebrovascular disease (e.g., stroke). Therefore, we now recognize that both systolic and diastolic pressure values are important to note. According to U.S. national guidelines (JNC 7 Report and JNC 8 Report), the following represents different stages of hypertension:
Two Classes of Hypertension
In 90-95% of patients presenting with hypertension, the cause is unknown. This condition is called primary (or essential) hypertension. The remaining 5-10% of hypertensive patients have hypertension that results secondarily from renal disease, endocrine disorders, or other identifiable causes. This form of hypertension is called secondary hypertension.
Hemodynamic Basis of Hypertension
Regardless of the origin of hypertension, the actual increase in arterial blood pressure is caused by either an increase in systemic vascular resistance (SVR) or an increase in cardiac output (CO). The former is determined by the vascular tone (i.e., state of constriction) of systemic resistance vessels, whereas the latter is determined by heart rate and stroke volume. Therefore, in order to understand how arterial blood pressure can become elevated, it is necessary to understand the mechanisms that regulate both SVR and CO.
Treatment of Hypertension
Most people with hypertension are treated with antihypertensive medications. In most forms of hypertension, the hypertensive state is maintained by an elevation in blood volume, which in turn increases cardiac output by the Frank-Starling relationship. Diuretic drugs, which enhance the removal of sodium and water by the kidneys and thereby decrease blood volume, are very effective in the treatment of hypertension. Hypertension is also commonly treated with drugs that decrease cardiac output. These cardioinhibitory drugs either block beta-adrenoceptors on the heart (i.e., beta-blockers) or L-type calcium channels (i.e., calcium-channel blockers), which decreases cardiac output by decreasing heart rate and contractility (inotropy). Vasodilator drugs, which decrease systemic vascular resistance, are also used to treat hypertension. Included in these drugs are alpha-adrenoceptor antagonists (alpha-blockers), direct-acting vasodilators, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. A complete list of drugs used to treat hypertension can be found by clicking here.
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