Image for Cardiovascular Physiology Concepts, Richard E Klabunde PhD

Cardiovascular Physiology Concepts

Richard E. Klabunde, PhD


Also Visit

Cardiovascular Physiology Concepts textbook cover

Click here for information on Cardiovascular Physiology Concepts, 2nd edition, a textbook published by Lippincott Williams & Wilkins (2011)

Cardiovascular Physiology Concepts textbook cover

Click here for information on Normal and Abnormal Blood Pressure, a textbook published by Richard E. Klabunde (2013)


Cardiac Cycle

intracardiac blood flow during systole and diastole

A single cycle of cardiac activity can be divided into two basic phases - diastole and systole

Diastole represents the period of time when the ventricles are relaxed (not contracting).Throughout most of this period, blood is passively flowing from the left atrium (LA) and right atrium (RA) into the left ventricle (LV) and right ventricle (RV), respectively (see figure at right). The blood flows through atrioventricular valves (mitral and tricuspid) that separate the atria from the ventricles. The RA receives venous blood from the body through the superior vena cava (SVC) and inferior vena cava (IVC). The LA receives oxygenated blood from lungs through four pulmonary veins that enter the LA. At the end of diastole, both atria contract, which propels an additional amount of blood into the ventricles.

Systole represents the time during which the left and right ventricles contract and eject blood into the aorta and pulmonary artery, respectively. During systole, the aortic and pulmonic valves open to permit ejection into the aorta and pulmonary artery. The atrioventricular valves are closed during systole, therefore no blood is entering the ventricles; however, blood continues to enter the atria though the vena cavae and pulmonary veins.

cardiac cycle diagram

The cardiac cycle diagram shown to the right depicts changes in aortic pressure (AP), left ventricular pressure (LVP), left atrial pressure (LAP), left ventricular volume (LV Vol), and heart sounds during a single cycle of cardiac contraction and relaxation. These changes are related in time to the electrocardiogram. An online video and tutorial of the cardiac cycle from the Health Education Assets Library is available: cardiac cycle video.

Aortic pressure is measured by inserting a pressure-measuring catheter into the aorta from a peripheral artery, and the left ventricular pressure is obtained by placing a catheter inside the left ventricle and measuring changes in intraventricular pressure as the heart beats. Left atrial pressure is not usually measured directly, except in investigational procedures; however, left atrial pressure can be estimated by recording the pulmonary capillary wedge pressure. Ventricular volume changes can be assessed in real time using echocardiography or radionuclide imaging, or by using a special volume conductance catheter placed within the ventricle.

To analyze systole and diastole in more detail, the cardiac cycle is usually divided into seven phases. The first phase begins with the P wave of the electrocardiogram, which represents atrial depolarization, and is the last phase of diastole. Phases 2-4 represent systole, and phases 5-7 represent early and mid-diastole. The last phase of the cardiac cycle ends with the appearance of the next P wave, which begins a new cycle. 

Detailed descriptions of each phase can be obtained by clicking on each of the seven phases listed below.

Mini-Lecture: Cardiac Cycle (Time = 14minutes)


Revised 07/01/15

DISCLAIMER: These materials are for educational purposes only, and are not a source of medical decision-making advice.